Title : Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes.

Pub. Date : 2006 Feb

PMID : 16239374






1 Functional Relationships(s)
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1 Although past studies have demonstrated decreased renal matrix metalloproteinase (MMP) activity in type 1 diabetes and in mesangial cells grown under high glucose conditions, renal MMP expression and activity in type 2 diabetes and the regulation of MMPs by profibrotic factors involved in diabetic renal complications such as endothelin-1 (ET-1) remained unknown. Glucose matrix metallopeptidase 14 Rattus norvegicus