Pub. Date : 2005 Oct
PMID : 16135096
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calpain-mediated truncation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 2 | Calpain-mediated truncation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity. | Hydrogen Peroxide | dihydropyrimidinase like 3 | Homo sapiens |
| 3 | In primary cortical cultures, glutamate (NMDA) excitotoxicity and oxidative stress (H2O2) caused the cleavage of DPYSL3, resulting in the appearance of a doublet of 62 kDa and 60 kDa. | Glutamic Acid | dihydropyrimidinase like 3 | Homo sapiens |
| 4 | In primary cortical cultures, glutamate (NMDA) excitotoxicity and oxidative stress (H2O2) caused the cleavage of DPYSL3, resulting in the appearance of a doublet of 62 kDa and 60 kDa. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 5 | In primary cortical cultures, glutamate (NMDA) excitotoxicity and oxidative stress (H2O2) caused the cleavage of DPYSL3, resulting in the appearance of a doublet of 62 kDa and 60 kDa. | Hydrogen Peroxide | dihydropyrimidinase like 3 | Homo sapiens |
| 6 | Furthermore, in vitro digestion of DPYSL3 in cell lysate with purified calpain revealed a cleavage product identical to that observed in NMDA- and H2O2-treated cells, and its appearance was blocked by calpain inhibitors. | N-Methylaspartate | dihydropyrimidinase like 3 | Homo sapiens |
| 7 | Furthermore, in vitro digestion of DPYSL3 in cell lysate with purified calpain revealed a cleavage product identical to that observed in NMDA- and H2O2-treated cells, and its appearance was blocked by calpain inhibitors. | Hydrogen Peroxide | dihydropyrimidinase like 3 | Homo sapiens |
| 8 | Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. | Valine | dihydropyrimidinase like 3 | Homo sapiens |
| 9 | Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. | Valine | dihydropyrimidinase like 3 | Homo sapiens |
| 10 | Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. | Arginine | dihydropyrimidinase like 3 | Homo sapiens |
| 11 | Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. | Arginine | dihydropyrimidinase like 3 | Homo sapiens |
| 12 | Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. | Serine | dihydropyrimidinase like 3 | Homo sapiens |
| 13 | Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. | Serine | dihydropyrimidinase like 3 | Homo sapiens |