PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16135096-0 2005 Calpain-mediated truncation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity. N-Methylaspartate 90-94 dihydropyrimidinase like 3 Homo sapiens 67-73 16135096-0 2005 Calpain-mediated truncation of dihydropyrimidinase-like 3 protein (DPYSL3) in response to NMDA and H2O2 toxicity. Hydrogen Peroxide 99-103 dihydropyrimidinase like 3 Homo sapiens 67-73 16135096-2 2005 In primary cortical cultures, glutamate (NMDA) excitotoxicity and oxidative stress (H2O2) caused the cleavage of DPYSL3, resulting in the appearance of a doublet of 62 kDa and 60 kDa. Glutamic Acid 30-39 dihydropyrimidinase like 3 Homo sapiens 113-119 16135096-2 2005 In primary cortical cultures, glutamate (NMDA) excitotoxicity and oxidative stress (H2O2) caused the cleavage of DPYSL3, resulting in the appearance of a doublet of 62 kDa and 60 kDa. N-Methylaspartate 41-45 dihydropyrimidinase like 3 Homo sapiens 113-119 16135096-2 2005 In primary cortical cultures, glutamate (NMDA) excitotoxicity and oxidative stress (H2O2) caused the cleavage of DPYSL3, resulting in the appearance of a doublet of 62 kDa and 60 kDa. Hydrogen Peroxide 84-88 dihydropyrimidinase like 3 Homo sapiens 113-119 16135096-4 2005 Furthermore, in vitro digestion of DPYSL3 in cell lysate with purified calpain revealed a cleavage product identical to that observed in NMDA- and H2O2-treated cells, and its appearance was blocked by calpain inhibitors. N-Methylaspartate 137-141 dihydropyrimidinase like 3 Homo sapiens 35-41 16135096-4 2005 Furthermore, in vitro digestion of DPYSL3 in cell lysate with purified calpain revealed a cleavage product identical to that observed in NMDA- and H2O2-treated cells, and its appearance was blocked by calpain inhibitors. Hydrogen Peroxide 147-151 dihydropyrimidinase like 3 Homo sapiens 35-41 16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Valine 87-90 dihydropyrimidinase like 3 Homo sapiens 16-22 16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Valine 87-90 dihydropyrimidinase like 3 Homo sapiens 121-127 16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Arginine 91-94 dihydropyrimidinase like 3 Homo sapiens 16-22 16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Arginine 91-94 dihydropyrimidinase like 3 Homo sapiens 121-127 16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Serine 95-98 dihydropyrimidinase like 3 Homo sapiens 16-22 16135096-5 2005 Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3. Serine 95-98 dihydropyrimidinase like 3 Homo sapiens 121-127