Title : What have we learnt from mouse models of NPM-ALK-induced lymphomagenesis?

Pub. Date : 2005 Jul

PMID : 15902287






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Activation of the NPM-ALK tyrosine kinase by NPM dimerisation causes autophosphorylation at multiple tyrosine residues and the consequent recruitment of a "signalosome" that couples the fusion protein to pathways regulating mitogenesis and apoptosis. Tyrosine nucleophosmin 1 Mus musculus
2 Activation of the NPM-ALK tyrosine kinase by NPM dimerisation causes autophosphorylation at multiple tyrosine residues and the consequent recruitment of a "signalosome" that couples the fusion protein to pathways regulating mitogenesis and apoptosis. Tyrosine nucleophosmin 1 Mus musculus