Title : Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen.

Pub. Date : 2005 Aug

PMID : 15900017






5 Functional Relationships(s)
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1 Other inhibitors of rOatps (taurocholate and pravastatin) and rOat3 (pravastatin and p-aminohippurate) had a slight effect, but digoxin had no effect. Pravastatin solute carrier family 22 member 8 Rattus norvegicus
2 Other inhibitors of rOatps (taurocholate and pravastatin) and rOat3 (pravastatin and p-aminohippurate) had a slight effect, but digoxin had no effect. p-Aminohippuric Acid solute carrier family 22 member 8 Rattus norvegicus
3 These results suggest that rOat2 accounts partly for the hepatic uptake of ketoprofen and, presumably, indomethacin as a high-affinity site and that other transporters, such as rOatps, but not rOatp2, and rOat3, are also involved. Ketoprofen solute carrier family 22 member 8 Rattus norvegicus
4 These results suggest that rOat2 accounts partly for the hepatic uptake of ketoprofen and, presumably, indomethacin as a high-affinity site and that other transporters, such as rOatps, but not rOatp2, and rOat3, are also involved. Indomethacin solute carrier family 22 member 8 Rattus norvegicus
5 These results suggest that rOat2 accounts partly for the hepatic uptake of ketoprofen and, presumably, indomethacin as a high-affinity site and that other transporters, such as rOatps, but not rOatp2, and rOat3, are also involved. roatps solute carrier family 22 member 8 Rattus norvegicus