PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15900017-11 2005 These results suggest that rOat2 accounts partly for the hepatic uptake of ketoprofen and, presumably, indomethacin as a high-affinity site and that other transporters, such as rOatps, but not rOatp2, and rOat3, are also involved. Ketoprofen 75-85 solute carrier family 22 member 7 Rattus norvegicus 27-32 15900017-0 2005 Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen. Ketoprofen 133-143 solute carrier family 22 member 7 Rattus norvegicus 30-57 15900017-0 2005 Functional involvement of rat organic anion transporter 2 (Slc22a7) in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen. Ketoprofen 133-143 solute carrier family 22 member 7 Rattus norvegicus 59-66 15900017-3 2005 rOat2 substrates include nonsteroidal anti-inflammatory drugs, such as ketoprofen, indomethacin, and salicylate. Ketoprofen 71-81 solute carrier family 22 member 7 Rattus norvegicus 0-5 15900017-3 2005 rOat2 substrates include nonsteroidal anti-inflammatory drugs, such as ketoprofen, indomethacin, and salicylate. Indomethacin 83-95 solute carrier family 22 member 7 Rattus norvegicus 0-5 15900017-3 2005 rOat2 substrates include nonsteroidal anti-inflammatory drugs, such as ketoprofen, indomethacin, and salicylate. Salicylates 101-111 solute carrier family 22 member 7 Rattus norvegicus 0-5 15900017-8 2005 The K(m) values of the high-affinity component were similar to those for rOat2 (3.3 and 0.37 microM for ketoprofen and indomethacin, respectively). Ketoprofen 104-114 solute carrier family 22 member 7 Rattus norvegicus 73-78 15900017-8 2005 The K(m) values of the high-affinity component were similar to those for rOat2 (3.3 and 0.37 microM for ketoprofen and indomethacin, respectively). Indomethacin 119-131 solute carrier family 22 member 7 Rattus norvegicus 73-78 15900017-9 2005 The uptake of ketoprofen by hepatocytes was significantly inhibited by probenecid and rOat2 inhibitors (indocyanine green, indomethacin, glibenclamide, and salicylate). Ketoprofen 14-24 solute carrier family 22 member 7 Rattus norvegicus 86-91 15900017-9 2005 The uptake of ketoprofen by hepatocytes was significantly inhibited by probenecid and rOat2 inhibitors (indocyanine green, indomethacin, glibenclamide, and salicylate). Indocyanine Green 104-121 solute carrier family 22 member 7 Rattus norvegicus 86-91 15900017-9 2005 The uptake of ketoprofen by hepatocytes was significantly inhibited by probenecid and rOat2 inhibitors (indocyanine green, indomethacin, glibenclamide, and salicylate). Indomethacin 123-135 solute carrier family 22 member 7 Rattus norvegicus 86-91 15900017-9 2005 The uptake of ketoprofen by hepatocytes was significantly inhibited by probenecid and rOat2 inhibitors (indocyanine green, indomethacin, glibenclamide, and salicylate). Glyburide 137-150 solute carrier family 22 member 7 Rattus norvegicus 86-91 15900017-9 2005 The uptake of ketoprofen by hepatocytes was significantly inhibited by probenecid and rOat2 inhibitors (indocyanine green, indomethacin, glibenclamide, and salicylate). Salicylates 156-166 solute carrier family 22 member 7 Rattus norvegicus 86-91 15900017-10 2005 Other inhibitors of rOatps (taurocholate and pravastatin) and rOat3 (pravastatin and p-aminohippurate) had a slight effect, but digoxin had no effect. Pravastatin 69-80 solute carrier family 22 member 8 Rattus norvegicus 62-67 15900017-10 2005 Other inhibitors of rOatps (taurocholate and pravastatin) and rOat3 (pravastatin and p-aminohippurate) had a slight effect, but digoxin had no effect. p-Aminohippuric Acid 85-101 solute carrier family 22 member 8 Rattus norvegicus 62-67 15900017-11 2005 These results suggest that rOat2 accounts partly for the hepatic uptake of ketoprofen and, presumably, indomethacin as a high-affinity site and that other transporters, such as rOatps, but not rOatp2, and rOat3, are also involved. Ketoprofen 75-85 solute carrier family 22 member 8 Rattus norvegicus 205-210 15900017-11 2005 These results suggest that rOat2 accounts partly for the hepatic uptake of ketoprofen and, presumably, indomethacin as a high-affinity site and that other transporters, such as rOatps, but not rOatp2, and rOat3, are also involved. Indomethacin 103-115 solute carrier family 22 member 7 Rattus norvegicus 27-32 15900017-11 2005 These results suggest that rOat2 accounts partly for the hepatic uptake of ketoprofen and, presumably, indomethacin as a high-affinity site and that other transporters, such as rOatps, but not rOatp2, and rOat3, are also involved. Indomethacin 103-115 solute carrier family 22 member 8 Rattus norvegicus 205-210 15900017-11 2005 These results suggest that rOat2 accounts partly for the hepatic uptake of ketoprofen and, presumably, indomethacin as a high-affinity site and that other transporters, such as rOatps, but not rOatp2, and rOat3, are also involved. roatps 177-183 solute carrier family 22 member 8 Rattus norvegicus 205-210