Title : Renal and systemic effects of chronic blockade of ET(A) or ET(B) receptors in normal rats and animals with experimental heart failure.

Pub. Date : 2004 Nov

PMID : 15838359






2 Functional Relationships(s)
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1 Furthermore, chronic administration of ABT-627 to controls attenuated the systemic and renal vasoconstriction induced by ET-1 (1 nmol/kg intravenous), whereas A-192621 augmented these effects. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid endothelin 1 Rattus norvegicus
2 Similarly, chronic treatment with ABT-627 totally abolished the systemic and renal vasoconstriction caused by injected ET-1 in rats with congestive heart failure, whereas A192621 potentiated these effects. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid endothelin 1 Rattus norvegicus