Title : Inhibition of interleukin-12 production in mouse macrophages via decreased nuclear factor-kappaB DNA binding activity by myricetin, a naturally occurring flavonoid.

Pub. Date : 2005 Mar

PMID : 15832812






4 Functional Relationships(s)
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1 Furthermore, activation of macrophages by LPS resulted in markedly enhanced binding activity to the NF-kappaB site, which significantly decreased upon addition of myricetin, indicating that myricetin inhibited IL-12 production in LPS-activated macrophages via the down-regulation of NF-kappaB binding activity. myricetin nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Furthermore, activation of macrophages by LPS resulted in markedly enhanced binding activity to the NF-kappaB site, which significantly decreased upon addition of myricetin, indicating that myricetin inhibited IL-12 production in LPS-activated macrophages via the down-regulation of NF-kappaB binding activity. myricetin nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 Furthermore, activation of macrophages by LPS resulted in markedly enhanced binding activity to the NF-kappaB site, which significantly decreased upon addition of myricetin, indicating that myricetin inhibited IL-12 production in LPS-activated macrophages via the down-regulation of NF-kappaB binding activity. myricetin nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
4 Furthermore, activation of macrophages by LPS resulted in markedly enhanced binding activity to the NF-kappaB site, which significantly decreased upon addition of myricetin, indicating that myricetin inhibited IL-12 production in LPS-activated macrophages via the down-regulation of NF-kappaB binding activity. myricetin nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus