Pub. Date : 2005 Apr
PMID : 15812237
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we showed by Northern blot a synergistic induction of the acute phase protein gene SAA2 with a combination of deacetylase inhibitors (Trichostatin A or NaBu) and IL-1beta in the colon carcinoma cell line Caco-2. | trichostatin A | serum amyloid A2 | Homo sapiens |
| 2 | In this study, we showed by Northern blot a synergistic induction of the acute phase protein gene SAA2 with a combination of deacetylase inhibitors (Trichostatin A or NaBu) and IL-1beta in the colon carcinoma cell line Caco-2. | sethoxydim | serum amyloid A2 | Homo sapiens |
| 3 | NaBu was sufficient to induce SAA2 expression after transient treatment with IL-1beta and, conversely, IL-1beta induced SAA2 after transient treatment with NaBu. | sethoxydim | serum amyloid A2 | Homo sapiens |
| 4 | NaBu was sufficient to induce SAA2 expression after transient treatment with IL-1beta and, conversely, IL-1beta induced SAA2 after transient treatment with NaBu. | sethoxydim | serum amyloid A2 | Homo sapiens |
| 5 | These data suggest that pretreatment with either NaBu or IL-1beta predisposes the SAA2 promoter to further stimulation. | sethoxydim | serum amyloid A2 | Homo sapiens |
| 6 | Indeed, both NaBu and IL-1beta led to increased recruitment of NF-kappa B p65, C/EBPbeta, and C/EBP delta, and decreased NF-kappa B p50 and C/EBP alpha DNA-binding to the proximal SAA2 promoter, as assessed by chromatin immunoprecipitation assays. | sethoxydim | serum amyloid A2 | Homo sapiens |
| 7 | Therefore, these results suggest that NaBu and IL- 1beta mediate SAA2 synergistic induction by establishing and maintaining similar and complementary chromatin modifications and transcription factor recruitment as well. | sethoxydim | serum amyloid A2 | Homo sapiens |