| Protein Name | serum amyloid A2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6289 |
| Gene Symbol | SAA2 |
| UniProt | P0DJI9 (SAA2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
17
Total Number of Articles : 15 |
Description |
serum amyloid A2 |
| Gene Summary |
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. [provided by RefSeq, Jul 2020] |
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| Properties | |