Pub. Date : 1992 Mar
PMID : 1576919
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differences in glucagon-like peptide-1 and GIP responses following sucrose ingestion. | Sucrose | gastric inhibitory polypeptide | Homo sapiens |
| 2 | To investigate the mechanism of oral carbohydrate-stimulated secretion of the two most potent incretin candidates, gastric inhibitory polypeptide (GIP) and truncated glucagon-like peptide-1 (tGLP-1), we studied the changes in the plasma levels of these peptides in five healthy men after sucrose ingestion with or without pretreatment with an alpha-D-glucosidase inhibitor (AO-128). | Carbohydrates | gastric inhibitory polypeptide | Homo sapiens |
| 3 | After sucrose ingestion, plasma levels of GIP peaked at 15 min and remained high up to 120 min. | Sucrose | gastric inhibitory polypeptide | Homo sapiens |
| 4 | After treatment with AO-128 (0.6 mg/day) for 1 week, increases in plasma glucose and insulin levels were attenuated and the increase in plasma GIP levels was diminished, while the increase in tGLP-1 levels was sustained much longer. | AO 128 | gastric inhibitory polypeptide | Homo sapiens |
| 5 | It is concluded that GIP secretion is stimulated by glucose absorption and tGLP-1 secretion by the presence of sucrose in the gut. | Glucose | gastric inhibitory polypeptide | Homo sapiens |
| 6 | It is concluded that GIP secretion is stimulated by glucose absorption and tGLP-1 secretion by the presence of sucrose in the gut. | Sucrose | gastric inhibitory polypeptide | Homo sapiens |