Pub. Date : 2005 Mar
PMID : 15767558
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15. | sulindac sulfide | growth differentiation factor 15 | Homo sapiens |
| 2 | The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15. | sulindac sulfide | growth differentiation factor 15 | Homo sapiens |
| 3 | The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15. | sulindac sulfide | growth differentiation factor 15 | Homo sapiens |
| 4 | Sulindac sulfide was the most significant NSAID activated gene 1 (NAG-1) inducer and its expression was inversely associated with cell viability as determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. | sulindac sulfide | growth differentiation factor 15 | Homo sapiens |
| 5 | Sulindac sulfide was the most significant NSAID activated gene 1 (NAG-1) inducer and its expression was inversely associated with cell viability as determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. | sulindac sulfide | growth differentiation factor 15 | Homo sapiens |
| 6 | Sulindac sulfide was the most significant NSAID activated gene 1 (NAG-1) inducer and its expression was inversely associated with cell viability as determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay. | 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium | growth differentiation factor 15 | Homo sapiens |
| 7 | This growth suppression by sulindac sulfide was recovered by transfection of NAG-1 small interfering RNA. | sulindac sulfide | growth differentiation factor 15 | Homo sapiens |
| 8 | These results indicate that NAG-1 is one of the genes responsible for growth suppression by sulindac sulfide. | sulindac sulfide | growth differentiation factor 15 | Homo sapiens |
| 9 | Furthermore, we observed down-regulation of p21 WAF1/CIP1 by introduction of NAG-1 small interfering RNA into sulindac sulfide-treated cells. | sulindac sulfide | growth differentiation factor 15 | Homo sapiens |