Title : Desensitization of the human motilin receptor by motilides.

Pub. Date : 2005 Jun

PMID : 15764739






3 Functional Relationships(s)
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1 In CHO-MTLR cells, the pDC(50) was ABT-229 (8.78) > motilin (7.77) > EM-A (4.78), different from their order of potency to induce Ca(2+) release (pEC(50)): motilin (9.39) > ABT-229 (8.46) > EM-A (7.11). 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid motilin receptor Homo sapiens
2 In cells with the EGFP-tagged MTLR, ABT-229 decreased membrane fluorescence by 25 +/- 2% compared with 16 +/- 2% for motilin and 8 +/- 2% for EM-A. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid motilin receptor Homo sapiens
3 In cells with the EGFP-tagged MTLR, ABT-229 decreased membrane fluorescence by 25 +/- 2% compared with 16 +/- 2% for motilin and 8 +/- 2% for EM-A. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid electron transfer flavoprotein subunit alpha Homo sapiens