Pub. Date : 2005 May 13
PMID : 15757899
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the current study, the regulation of NAG-1 expression in LNCaP human prostate carcinoma cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) was examined. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 2 | In the current study, the regulation of NAG-1 expression in LNCaP human prostate carcinoma cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) was examined. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 3 | TPA treatment increased NAG-1 protein and mRNA levels in a time- and concentration-dependent manner as well as NF-kappa B binding/transcriptional activity in LNCaP cells. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 4 | Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 5 | Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 6 | Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 7 | Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 8 | Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 9 | Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 10 | Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 11 | Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |
| 12 | These results demonstrate that NAG-1 expression is up-regulated by TPA in LNCaP cells through a PKC-dependent pathway involving the activation of NF-kappa B. | Tetradecanoylphorbol Acetate | growth differentiation factor 15 | Homo sapiens |