Pub. Date : 2005 Jun 2
PMID : 15750625
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin. | Cisplatin | Bloom syndrome, RecQ like helicase | Mus musculus |
| 2 | Downregulation of BLM by antisense cDNA or dominant-negative mutant inhibits homologous recombination repair (HRR) and increases sensitivity to cisplatin in BCR/ABL-positive cells. | Cisplatin | Bloom syndrome, RecQ like helicase | Mus musculus |
| 3 | Bone marrow cells from mice heterozygous for BLM mutation, BLM(Cin/+), transfected with BCR/ABL display increased sensitivity to cisplatin compared to those obtained from the wild-type littermates. | Cisplatin | Bloom syndrome, RecQ like helicase | Mus musculus |
| 4 | Bone marrow cells from mice heterozygous for BLM mutation, BLM(Cin/+), transfected with BCR/ABL display increased sensitivity to cisplatin compared to those obtained from the wild-type littermates. | Cisplatin | Bloom syndrome, RecQ like helicase | Mus musculus |