Protein Name Bloom syndrome, RecQ like helicase
Organism Mus musculus
Gene ID 12144
Gene Symbol

Blm

UniProt O88700 (BLM_MOUSE), E9PZ97 (E9PZ97_MOUSE)
Relationships Total Number of functionally related compound(s) : 19
Total Number of Articles : 17
Description

Bloom syndrome, RecQ like helicase

Gene Summary

Enables 3'-5' DNA helicase activity. Involved in DNA geometric change; negative regulation of mitotic recombination; and replication fork processing. Acts upstream of or within several processes, including DNA metabolic process; T cell differentiation; and positive regulation of T cell proliferation. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and mammary gland. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Bloom syndrome. Orthologous to human BLM (BLM RecQ like helicase). [provided by Alliance of Genome Resources, Jul 2025]

synonyms
  • recQ-like DNA helicase BLM
  • Bloom syndrome homolog
  • Bloom syndrome, RecQ helicase-like
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Properties