Title : A nonspecific phosphotyrosine phosphatase inhibitor, bis(maltolato)oxovanadium(IV), improves glucose tolerance and prevents diabetes in Zucker diabetic fatty rats.

Pub. Date : 2005 Mar

PMID : 15734724






1 Functional Relationships(s)
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1 Insulin-mediated signal transduction is negatively regulated by the phosphotyrosine phosphatase, PTP1B, and numerous studies have demonstrated that organo-vanadium compounds, which are nonselective phosphotyrosine phosphatase inhibitors, have insulin-mimetic properties. organo-vanadium compounds protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus