Pub. Date : 2005 Feb
PMID : 15667273
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nar1p, a conserved eukaryotic protein with similarity to Fe-only hydrogenases, functions in cytosolic iron-sulphur protein biogenesis. | Iron | iron-sulfur cluster assembly protein NAR1 | Saccharomyces cerevisiae S288C |
| 2 | Previously, we have shown that Nar1p is an Fe-S protein and that assembly of its co-factors depends on the mitochondrial Fe-S cluster biosynthesis apparatus. | Iron | iron-sulfur cluster assembly protein NAR1 | Saccharomyces cerevisiae S288C |
| 3 | Using functional studies in vivo, we demonstrated that Nar1p has an essential role in the maturation of cytosolic and nuclear, but not of mitochondrial, Fe-S proteins. | Iron | iron-sulfur cluster assembly protein NAR1 | Saccharomyces cerevisiae S288C |
| 4 | Here we provide further spectroscopic evidence that Nar1p possesses two Fe-S clusters. | Iron | iron-sulfur cluster assembly protein NAR1 | Saccharomyces cerevisiae S288C |
| 5 | We also show that Nar1p is required for Fe-S cluster assembly on the P-loop NTPase Nbp35p, another newly identified component of the cytosolic Fe-S protein assembly machinery. | Iron | iron-sulfur cluster assembly protein NAR1 | Saccharomyces cerevisiae S288C |
| 6 | We also show that Nar1p is required for Fe-S cluster assembly on the P-loop NTPase Nbp35p, another newly identified component of the cytosolic Fe-S protein assembly machinery. | Iron | iron-sulfur cluster assembly protein NAR1 | Saccharomyces cerevisiae S288C |