Pub. Date : 2004 Dec
PMID : 15564778
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma. | Bleomycin | interleukin 13 | Mus musculus |
| 2 | RESULTS: RT-PCR showed that both IL-4 and IL-13 mRNA levels in skin lesions were increased and peaked after 4 weeks of bleomycin treatment. | Bleomycin | interleukin 13 | Mus musculus |
| 3 | In skin lesions, IL-13 receptor (IL-13R) alpha2 expression was augmented mainly in the infiltrating mononuclear cells after 4 weeks of bleomycin exposure. | Bleomycin | interleukin 13 | Mus musculus |
| 4 | CONCLUSION: These data demonstrate that in skin lesions levels of IL-13 as well as its receptor increase in parallel with DSc progression, suggesting that IL-13 promotes the progression of cutaneous fibrosis/sclerosis in the murine model of bleomycin-induced scleroderma. | Bleomycin | interleukin 13 | Mus musculus |
| 5 | CONCLUSION: These data demonstrate that in skin lesions levels of IL-13 as well as its receptor increase in parallel with DSc progression, suggesting that IL-13 promotes the progression of cutaneous fibrosis/sclerosis in the murine model of bleomycin-induced scleroderma. | Bleomycin | interleukin 13 | Mus musculus |