PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15564778-0 2004 Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma. Bleomycin 69-78 interleukin 13 Mus musculus 16-30 15564778-6 2004 RESULTS: RT-PCR showed that both IL-4 and IL-13 mRNA levels in skin lesions were increased and peaked after 4 weeks of bleomycin treatment. Bleomycin 119-128 interleukin 4 Mus musculus 33-37 15564778-6 2004 RESULTS: RT-PCR showed that both IL-4 and IL-13 mRNA levels in skin lesions were increased and peaked after 4 weeks of bleomycin treatment. Bleomycin 119-128 interleukin 13 Mus musculus 42-47 15564778-10 2004 In skin lesions, IL-13 receptor (IL-13R) alpha2 expression was augmented mainly in the infiltrating mononuclear cells after 4 weeks of bleomycin exposure. Bleomycin 135-144 interleukin 13 Mus musculus 17-22 15564778-10 2004 In skin lesions, IL-13 receptor (IL-13R) alpha2 expression was augmented mainly in the infiltrating mononuclear cells after 4 weeks of bleomycin exposure. Bleomycin 135-144 interleukin 13 receptor, alpha 2 Mus musculus 33-47 15564778-12 2004 On the contrary, mRNA expression of IL-13Ralpha1 and IL- 13Ralpha2 was significantly altered in the cultured fibroblasts derived from bleomycin-treated skin. Bleomycin 134-143 interleukin 13 receptor, alpha 1 Mus musculus 36-48 15564778-12 2004 On the contrary, mRNA expression of IL-13Ralpha1 and IL- 13Ralpha2 was significantly altered in the cultured fibroblasts derived from bleomycin-treated skin. Bleomycin 134-143 interleukin 13 receptor, alpha 2 Mus musculus 53-66 15564778-13 2004 CONCLUSION: These data demonstrate that in skin lesions levels of IL-13 as well as its receptor increase in parallel with DSc progression, suggesting that IL-13 promotes the progression of cutaneous fibrosis/sclerosis in the murine model of bleomycin-induced scleroderma. Bleomycin 241-250 interleukin 13 Mus musculus 66-71 15564778-13 2004 CONCLUSION: These data demonstrate that in skin lesions levels of IL-13 as well as its receptor increase in parallel with DSc progression, suggesting that IL-13 promotes the progression of cutaneous fibrosis/sclerosis in the murine model of bleomycin-induced scleroderma. Bleomycin 241-250 interleukin 13 Mus musculus 155-160