Title : Synthesis and biodistribution of [18F]FE@CIT, a new potential tracer for the dopamine transporter.

Pub. Date : 2005 Feb

PMID : 15529336






5 Functional Relationships(s)
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1 In the last decade radiolabeled tropane analogs based on beta-CIT have proven indispensable for the imaging of the dopamine transporter. Tropanes citron rho-interacting serine/threonine kinase Rattus norvegicus
2 An important improvement, yielding in higher affinity to the dopamine transporter (DAT) vs. serotonin transporter (SERT), can be achieved by a simple replacement of the carboxylic methyl ester group in beta-CIT by a fluoroethyl ester. methyl ester citron rho-interacting serine/threonine kinase Rattus norvegicus
3 An important improvement, yielding in higher affinity to the dopamine transporter (DAT) vs. serotonin transporter (SERT), can be achieved by a simple replacement of the carboxylic methyl ester group in beta-CIT by a fluoroethyl ester. fluoroethyl ester citron rho-interacting serine/threonine kinase Rattus norvegicus
4 [18F]FE@CIT was prepared by distillation of [18F]bromofluoroethane ([18F]BFE) and reaction with (1R-2-exo-3-exo)8-methyl-3-(4-iodo-phenyl)-8-azabicyclo[3.2.1] octane-2-carboxylic acid. [18f]bromofluoroethane citron rho-interacting serine/threonine kinase Rattus norvegicus
5 [18F]FE@CIT was prepared by distillation of [18F]bromofluoroethane ([18F]BFE) and reaction with (1R-2-exo-3-exo)8-methyl-3-(4-iodo-phenyl)-8-azabicyclo[3.2.1] octane-2-carboxylic acid. (1r-2-exo-3-exo)8-methyl-3-(4-iodo-phenyl)-8-azabicyclo[3.2.1] octane-2-carboxylic acid citron rho-interacting serine/threonine kinase Rattus norvegicus