Title : Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid.

Pub. Date : 1992 Apr

PMID : 1552361






3 Functional Relationships(s)
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1 In addition, AA-2G-induced stimulation of collagen synthesis could be completely inhibited by the addition of castanospermine, an inhibitor of neutral alpha-glucosidase. castanospermine sucrase-isomaltase Homo sapiens
2 Relatively high alpha-glucosidase activity, which would contribute to release of ascorbic acid from AA-2G, could be detected in the lysate of cultured fibroblasts. Ascorbic Acid sucrase-isomaltase Homo sapiens
3 These results indicate that AA-2G is gradually cleaved by the cellular alpha-glucosidase to release L-ascorbic acid, which adequately stimulates collagen synthesis and proliferation of human skin fibroblasts. Ascorbic Acid sucrase-isomaltase Homo sapiens