Pub. Date : 2004 Aug
PMID : 15460448
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of CYP1A1 expression by naringenin in murine Hepa-1c1c7 cells. | naringenin | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 2 | In the present study, we investigated the effect of naringenin on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible CYP1A1 gene expression in mouse hepatoma Hepa-1c1c7 cells. | naringenin | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 3 | TCDD-induced CYP1A1 mRNA level was also markedly suppressed by naringenin. | naringenin | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 4 | A transient transfection assay using dioxin-response element (DRE)-linked luciferase and electrophoretic mobility shift assay revealed that naringenin reduced transformation of the aryl hydrocarbons receptor(AhR) to a form capable of specifically binding to the DRE sequence in the promoter of the CYP1A1 gene. | naringenin | aryl-hydrocarbon receptor | Mus musculus |
| 5 | A transient transfection assay using dioxin-response element (DRE)-linked luciferase and electrophoretic mobility shift assay revealed that naringenin reduced transformation of the aryl hydrocarbons receptor(AhR) to a form capable of specifically binding to the DRE sequence in the promoter of the CYP1A1 gene. | naringenin | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 6 | These results suggest the down regulation of the CYP1A1 gene expression by either naringenin in Hepa-1c1c7 cells might be antagonism of the DRE binding potential of nuclear AhR. | naringenin | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 7 | These results suggest the down regulation of the CYP1A1 gene expression by either naringenin in Hepa-1c1c7 cells might be antagonism of the DRE binding potential of nuclear AhR. | naringenin | aryl-hydrocarbon receptor | Mus musculus |