Title : Studies on the receptors mediating responses of osteoblasts to thrombin.

Pub. Date : 2005 Jan

PMID : 15381162






2 Functional Relationships(s)
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1 Primary mouse calvarial osteoblasts from PAR-1-null and wild-type mice, and synthetic peptides that specifically activate PAR-1 (TFFLR-NH2) and PAR-4 (AYPGKF-NH2) were used. Peptides coagulation factor II (thrombin) receptor Mus musculus
2 Both the PAR-1-activating peptide and thrombin stimulated incorporation of 5-bromo-2"-deoxyuridine (two to four-fold, P < 0.001) and reduced alkaline phosphatase activity (approximately three-fold, P < 0.05) in cells from wild-type mice. Bromodeoxyuridine coagulation factor II (thrombin) receptor Mus musculus