Title : Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide.

Pub. Date : 2004 Jul 7

PMID : 15240796






7 Functional Relationships(s)
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1 Evidence is presented in this study that the Abeta-mediated inhibition of LTP induction involves activation of microglia and production of reactive oxygen and nitrogen species. reactive oxygen and nitrogen species histocompatibility 2, class II antigen A, beta 1 Mus musculus
2 The Abeta-mediated inhibition of LTP induction also was prevented by the superoxide scavenger superoxide dismutase applied together with catalase. Superoxides histocompatibility 2, class II antigen A, beta 1 Mus musculus
3 Evidence for involvement of superoxide in the action of Abeta on LTP induction was shown by the ability of an inhibitor of NADPH oxidase to prevent the Abeta-mediated inhibition of LTP induction. Superoxides histocompatibility 2, class II antigen A, beta 1 Mus musculus
4 Evidence for involvement of superoxide in the action of Abeta on LTP induction was shown by the ability of an inhibitor of NADPH oxidase to prevent the Abeta-mediated inhibition of LTP induction. Superoxides histocompatibility 2, class II antigen A, beta 1 Mus musculus
5 The study thus provides evidence that the Abeta-mediated inhibition of LTP induction involves an inflammatory-type reaction in which activation of microglia results in the production of nitric oxide and superoxide and thence possibly peroxynitrite, a highly reactive oxidant. Nitric Oxide histocompatibility 2, class II antigen A, beta 1 Mus musculus
6 The study thus provides evidence that the Abeta-mediated inhibition of LTP induction involves an inflammatory-type reaction in which activation of microglia results in the production of nitric oxide and superoxide and thence possibly peroxynitrite, a highly reactive oxidant. Superoxides histocompatibility 2, class II antigen A, beta 1 Mus musculus
7 The study thus provides evidence that the Abeta-mediated inhibition of LTP induction involves an inflammatory-type reaction in which activation of microglia results in the production of nitric oxide and superoxide and thence possibly peroxynitrite, a highly reactive oxidant. Peroxynitrous Acid histocompatibility 2, class II antigen A, beta 1 Mus musculus