Pub. Date : 2004 Jul
PMID : 15213852
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AR-C69931MX (10 microM), a specific antagonist of the Gi-coupled P2Y12 ADP receptor, inhibits ERK2 activation induced by thrombin. | cangrelor | purinergic receptor P2Y12 | Homo sapiens |
| 2 | Stimulating the Gq-coupled TXA2 -receptor with U46619 (10 microM), which leads to ADP secretion and P2Y12 receptor-dependent platelet aggregation, also induces P2Y12-related ERK2 activation. | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid | purinergic receptor P2Y12 | Homo sapiens |
| 3 | Stimulating the Gq-coupled TXA2 -receptor with U46619 (10 microM), which leads to ADP secretion and P2Y12 receptor-dependent platelet aggregation, also induces P2Y12-related ERK2 activation. | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid | purinergic receptor P2Y12 | Homo sapiens |
| 4 | Stimulating the Gq-coupled TXA2 -receptor with U46619 (10 microM), which leads to ADP secretion and P2Y12 receptor-dependent platelet aggregation, also induces P2Y12-related ERK2 activation. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 5 | Our data indicate that both primary signalling through Gq, which evokes ADP secretion, as well as subsequent coupling via Gi by the P2Y12 receptor are required for ERK2 activation. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |