Title : Cloning and pharmacological characterisation of the guinea pig 5-ht5A receptor.

Pub. Date : 2004 Jun 28

PMID : 15212962






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 [(3)H]-Lysergic acid diethylamide (LSD) bound saturably to gp5-ht(5A)/HEK293 membranes with a K(d) of 2.3+/-0.1 nM and B(max) of 15.7+/-3.4 pmol/mg protein. [(3)h]-lysergic acid diethylamide glycoprotein V platelet Homo sapiens
2 5-HT stimulated [(35)S]GTPgammaS binding to gp5-ht(5A)/HEK293 membranes (pEC(50) 8.1+/-0.2), and the response was surmountably antagonised by methiothepin and ritanserin, giving apparent pK(B) values of 8.0 and 7.2, respectively. Methiothepin glycoprotein V platelet Homo sapiens
3 5-HT stimulated [(35)S]GTPgammaS binding to gp5-ht(5A)/HEK293 membranes (pEC(50) 8.1+/-0.2), and the response was surmountably antagonised by methiothepin and ritanserin, giving apparent pK(B) values of 8.0 and 7.2, respectively. Ritanserin glycoprotein V platelet Homo sapiens