| Protein Name | glycoprotein V platelet |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2814 |
| Gene Symbol | GP5 |
| UniProt | P40197 (GPV_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
64
Total Number of Articles : 57 |
Description |
glycoprotein V platelet |
| Gene Summary |
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010] |
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| Properties | |