Title : The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons.

Pub. Date : 2004 Jun

PMID : 15209419






6 Functional Relationships(s)
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1 In the present study, we tested whether inhibition of protein-tyrosine phosphatases (PTP) by orthovanadate could enhance tyrosine phosphorylation of TrkA thereby stimulating NGF-like survival signaling in embryonic hippocampal neurons. Vanadates protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
2 In the present study, we tested whether inhibition of protein-tyrosine phosphatases (PTP) by orthovanadate could enhance tyrosine phosphorylation of TrkA thereby stimulating NGF-like survival signaling in embryonic hippocampal neurons. Vanadates protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
3 In the present study, we tested whether inhibition of protein-tyrosine phosphatases (PTP) by orthovanadate could enhance tyrosine phosphorylation of TrkA thereby stimulating NGF-like survival signaling in embryonic hippocampal neurons. Tyrosine protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
4 We found that the PTP inhibitor orthovanadate (1 microM) enhanced TrkA phosphorylation and protected neurons against staurosporine (STS)-induced apoptosis in a time-and concentration-dependent manner. Vanadates protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
5 We found that the PTP inhibitor orthovanadate (1 microM) enhanced TrkA phosphorylation and protected neurons against staurosporine (STS)-induced apoptosis in a time-and concentration-dependent manner. Staurosporine protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
6 We found that the PTP inhibitor orthovanadate (1 microM) enhanced TrkA phosphorylation and protected neurons against staurosporine (STS)-induced apoptosis in a time-and concentration-dependent manner. Staurosporine protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus