Pub. Date : 2004 Sep
PMID : 15192074
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show here that 17 beta-estradiol promoted a 6-fold increase in Jagged1 expression and an 8-fold increase in Notch1 expression by cDNA arrays in breast cancer MCF7 cells. | Estradiol | jagged canonical Notch ligand 1 | Homo sapiens |
| 2 | Treatment with 17 beta-estradiol also led to an activation of Notch signaling in MCF7 cells expressing Notch1 reporter gene or by promoting Jagged1-induced Notch signaling in coculture assays. | Estradiol | jagged canonical Notch ligand 1 | Homo sapiens |