Title : Simultaneous exposure of rats to dioxin and carbon monoxide reduces the xenobiotic but not the hypoxic response.

Pub. Date : 2004 Mar-Apr

PMID : 15134343






2 Functional Relationships(s)
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1 Whereas the environmentally toxic compound 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) initiates the trans-activation activity of AhR:ARNT/HIF-1beta, hypoxic exposure stabilizes HIF-1alpha and functionally activates the HIF-1alpha:ARNT/HIF-1beta complex. Polychlorinated Dibenzodioxins hypoxia inducible factor 1 subunit alpha Rattus norvegicus
2 Whereas the environmentally toxic compound 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) initiates the trans-activation activity of AhR:ARNT/HIF-1beta, hypoxic exposure stabilizes HIF-1alpha and functionally activates the HIF-1alpha:ARNT/HIF-1beta complex. Polychlorinated Dibenzodioxins hypoxia inducible factor 1 subunit alpha Rattus norvegicus