Protein Name hypoxia inducible factor 1 subunit alpha
Organism Rattus norvegicus
Gene ID 29560
Gene Symbol


UniProt O35800 (HIF1A_RAT), D4A8P8 (D4A8P8_RAT)
Relationships Total Number of functionally related compound(s) : 661
Total Number of Articles : 1064

hypoxia inducible factor 1 subunit alpha

Gene Summary

Enables sequence-specific DNA binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to carbon monoxide; regulation of apoptotic process; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Used to study acute kidney failure; brain ischemia; diabetic retinopathy; hepatocellular carcinoma; and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; decubitus ulcer; ischemia (multiple); and kidney failure (multiple). Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

  • hypoxia-inducible factor 1-alpha
  • HIF1 alpha
  • hypoxia inducible factor 1 alpha subunit
Click to show/hide the synonyms