Pub. Date : 2004 Jul 2
PMID : 15090548
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 2 | CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter. | Hemicholinium 3 | solute carrier family 5 member 7 | Homo sapiens |
| 3 | CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter. | Hemicholinium 3 | solute carrier family 5 member 7 | Homo sapiens |
| 4 | CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter. | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 5 | We now report that Par-4 is a negative regulator of CHT1 choline uptake activity. | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 6 | Transfection of neural IMR-32 cells with human CHT1 conferred Na(+)-dependent, HC-3-sensitive choline uptake that was effectively inhibited by cotransfection of Par-4. | Hemicholinium 3 | solute carrier family 5 member 7 | Homo sapiens |
| 7 | Transfection of neural IMR-32 cells with human CHT1 conferred Na(+)-dependent, HC-3-sensitive choline uptake that was effectively inhibited by cotransfection of Par-4. | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 8 | Kinetic and cell-surface biotinylation assays showed that Par-4 inhibited CHT1-mediated choline uptake by reducing CHT1 expression in the plasma membrane without significantly altering the affinity of CHT1 for choline or HC-3. | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 9 | Kinetic and cell-surface biotinylation assays showed that Par-4 inhibited CHT1-mediated choline uptake by reducing CHT1 expression in the plasma membrane without significantly altering the affinity of CHT1 for choline or HC-3. | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 10 | Kinetic and cell-surface biotinylation assays showed that Par-4 inhibited CHT1-mediated choline uptake by reducing CHT1 expression in the plasma membrane without significantly altering the affinity of CHT1 for choline or HC-3. | Choline | solute carrier family 5 member 7 | Homo sapiens |
| 11 | These results suggest that Par-4 is directly involved in regulating choline uptake by interacting with CHT1 and by reducing its incorporation on the cell surface. | Choline | solute carrier family 5 member 7 | Homo sapiens |