PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15090548-0 2004 Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. Choline 15-22 pro-apoptotic WT1 regulator Homo sapiens 0-5 15090548-0 2004 Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. Choline 15-22 solute carrier family 5 member 7 Homo sapiens 50-54 15090548-1 2004 CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter. Hemicholinium 3 38-53 solute carrier family 5 member 7 Homo sapiens 0-4 15090548-1 2004 CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter. Hemicholinium 3 55-60 solute carrier family 5 member 7 Homo sapiens 0-4 15090548-1 2004 CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter. Choline 86-93 solute carrier family 5 member 7 Homo sapiens 0-4 15090548-3 2004 We now report that Par-4 is a negative regulator of CHT1 choline uptake activity. Choline 57-64 pro-apoptotic WT1 regulator Homo sapiens 19-24 15090548-3 2004 We now report that Par-4 is a negative regulator of CHT1 choline uptake activity. Choline 57-64 solute carrier family 5 member 7 Homo sapiens 52-56 15090548-4 2004 Transfection of neural IMR-32 cells with human CHT1 conferred Na(+)-dependent, HC-3-sensitive choline uptake that was effectively inhibited by cotransfection of Par-4. Hemicholinium 3 79-83 solute carrier family 5 member 7 Homo sapiens 47-51 15090548-4 2004 Transfection of neural IMR-32 cells with human CHT1 conferred Na(+)-dependent, HC-3-sensitive choline uptake that was effectively inhibited by cotransfection of Par-4. Hemicholinium 3 79-83 pro-apoptotic WT1 regulator Homo sapiens 161-166 15090548-4 2004 Transfection of neural IMR-32 cells with human CHT1 conferred Na(+)-dependent, HC-3-sensitive choline uptake that was effectively inhibited by cotransfection of Par-4. Choline 94-101 solute carrier family 5 member 7 Homo sapiens 47-51 15090548-4 2004 Transfection of neural IMR-32 cells with human CHT1 conferred Na(+)-dependent, HC-3-sensitive choline uptake that was effectively inhibited by cotransfection of Par-4. Choline 94-101 pro-apoptotic WT1 regulator Homo sapiens 161-166 15090548-5 2004 Mapping studies indicated that the C-terminal half of Par-4 was physically involved in interacting with CHT1, and the absence of Par-4.CHT1 complex formation precluded the loss of CHT1-mediated choline uptake induced by Par-4, indicating that Par-4.CHT1 complex formation is essential. Choline 194-201 pro-apoptotic WT1 regulator Homo sapiens 54-59 15090548-6 2004 Kinetic and cell-surface biotinylation assays showed that Par-4 inhibited CHT1-mediated choline uptake by reducing CHT1 expression in the plasma membrane without significantly altering the affinity of CHT1 for choline or HC-3. Choline 88-95 pro-apoptotic WT1 regulator Homo sapiens 58-63 15090548-6 2004 Kinetic and cell-surface biotinylation assays showed that Par-4 inhibited CHT1-mediated choline uptake by reducing CHT1 expression in the plasma membrane without significantly altering the affinity of CHT1 for choline or HC-3. Choline 88-95 solute carrier family 5 member 7 Homo sapiens 74-78 15090548-6 2004 Kinetic and cell-surface biotinylation assays showed that Par-4 inhibited CHT1-mediated choline uptake by reducing CHT1 expression in the plasma membrane without significantly altering the affinity of CHT1 for choline or HC-3. Choline 88-95 solute carrier family 5 member 7 Homo sapiens 115-119 15090548-6 2004 Kinetic and cell-surface biotinylation assays showed that Par-4 inhibited CHT1-mediated choline uptake by reducing CHT1 expression in the plasma membrane without significantly altering the affinity of CHT1 for choline or HC-3. Choline 88-95 solute carrier family 5 member 7 Homo sapiens 115-119 15090548-7 2004 These results suggest that Par-4 is directly involved in regulating choline uptake by interacting with CHT1 and by reducing its incorporation on the cell surface. Choline 68-75 pro-apoptotic WT1 regulator Homo sapiens 27-32 15090548-7 2004 These results suggest that Par-4 is directly involved in regulating choline uptake by interacting with CHT1 and by reducing its incorporation on the cell surface. Choline 68-75 solute carrier family 5 member 7 Homo sapiens 103-107