Pub. Date : 2004 Feb
PMID : 15084352
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In order to investigate the link between PPARalpha and cholesterol synthesis, we analysed the effect of fibrates on expression of the farnesyl diphosphate synthase (FPP synthase) gene, known to be regulated by sterol regulatory element-binding proteins (SREBPs), in conjunction with HMG-CoA reductase. | Cholesterol | farnesyl diphosphate synthetase | Mus musculus |
| 2 | In order to investigate the link between PPARalpha and cholesterol synthesis, we analysed the effect of fibrates on expression of the farnesyl diphosphate synthase (FPP synthase) gene, known to be regulated by sterol regulatory element-binding proteins (SREBPs), in conjunction with HMG-CoA reductase. | Cholesterol | farnesyl diphosphate synthetase | Mus musculus |
| 3 | In wild-type mice, both fenofibrate and WY 14,643 induced FPP synthase gene expression, an effect impaired in PPARalpha-null mice. | Fenofibrate | farnesyl diphosphate synthetase | Mus musculus |
| 4 | In addition, induction of FPP synthase gene expression was abolished in the presence of 25-hydroxycholesterol (25-OH Chol). | 25-hydroxycholesterol | farnesyl diphosphate synthetase | Mus musculus |
| 5 | In addition, induction of FPP synthase gene expression was abolished in the presence of 25-hydroxycholesterol (25-OH Chol). | 25-oh chol | farnesyl diphosphate synthetase | Mus musculus |