PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15084352-2 2004 In order to investigate the link between PPARalpha and cholesterol synthesis, we analysed the effect of fibrates on expression of the farnesyl diphosphate synthase (FPP synthase) gene, known to be regulated by sterol regulatory element-binding proteins (SREBPs), in conjunction with HMG-CoA reductase. Cholesterol 55-66 farnesyl diphosphate synthetase Mus musculus 134-163 15084352-2 2004 In order to investigate the link between PPARalpha and cholesterol synthesis, we analysed the effect of fibrates on expression of the farnesyl diphosphate synthase (FPP synthase) gene, known to be regulated by sterol regulatory element-binding proteins (SREBPs), in conjunction with HMG-CoA reductase. Cholesterol 55-66 farnesyl diphosphate synthetase Mus musculus 165-177 15084352-3 2004 In wild-type mice, both fenofibrate and WY 14,643 induced FPP synthase gene expression, an effect impaired in PPARalpha-null mice. Fenofibrate 24-35 farnesyl diphosphate synthetase Mus musculus 58-70 15084352-3 2004 In wild-type mice, both fenofibrate and WY 14,643 induced FPP synthase gene expression, an effect impaired in PPARalpha-null mice. Fenofibrate 24-35 peroxisome proliferator activated receptor alpha Mus musculus 110-119 15084352-7 2004 In addition, induction of FPP synthase gene expression was abolished in the presence of 25-hydroxycholesterol (25-OH Chol). 25-hydroxycholesterol 88-109 farnesyl diphosphate synthetase Mus musculus 26-38 15084352-7 2004 In addition, induction of FPP synthase gene expression was abolished in the presence of 25-hydroxycholesterol (25-OH Chol). 25-oh chol 111-121 farnesyl diphosphate synthetase Mus musculus 26-38