Pub. Date : 2004 Apr 20
PMID : 15069188
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TRPM7 is a ubiquitously expressed and constitutively active divalent cation-selective ion channel, whose basal activity is regulated by intracellular levels of Mg(2+) and Mg.ATP. | Magnesium | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 2 | TRPM7 is a ubiquitously expressed and constitutively active divalent cation-selective ion channel, whose basal activity is regulated by intracellular levels of Mg(2+) and Mg.ATP. | Magnesium | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 3 | TRPM7 is a ubiquitously expressed and constitutively active divalent cation-selective ion channel, whose basal activity is regulated by intracellular levels of Mg(2+) and Mg.ATP. | Adenosine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 4 | Consistent with the involvement of G(s)/G(i) in controlling adenylyl cyclase activity, elevations of intracellular cAMP levels enhance TRPM7 activity and prevent receptor-mediated modulation of TRPM7 activity by muscarinic and adrenergic agonists. | Cyclic AMP | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 5 | Consistent with the involvement of G(s)/G(i) in controlling adenylyl cyclase activity, elevations of intracellular cAMP levels enhance TRPM7 activity and prevent receptor-mediated modulation of TRPM7 activity by muscarinic and adrenergic agonists. | Cyclic AMP | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 6 | This cAMP-dependent effect requires the functional integrity of both protein kinase A (PKA) and the endogenous kinase domain of TRPM7 because cAMP-mediated effects are abolished when treating cells with the PKA inhibitors H89 or KT5720 as well as in cells expressing phosphotransferase-deficient TRPM7 constructs. | Cyclic AMP | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 7 | This cAMP-dependent effect requires the functional integrity of both protein kinase A (PKA) and the endogenous kinase domain of TRPM7 because cAMP-mediated effects are abolished when treating cells with the PKA inhibitors H89 or KT5720 as well as in cells expressing phosphotransferase-deficient TRPM7 constructs. | Cyclic AMP | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 8 | This cAMP-dependent effect requires the functional integrity of both protein kinase A (PKA) and the endogenous kinase domain of TRPM7 because cAMP-mediated effects are abolished when treating cells with the PKA inhibitors H89 or KT5720 as well as in cells expressing phosphotransferase-deficient TRPM7 constructs. | Cyclic AMP | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 9 | This cAMP-dependent effect requires the functional integrity of both protein kinase A (PKA) and the endogenous kinase domain of TRPM7 because cAMP-mediated effects are abolished when treating cells with the PKA inhibitors H89 or KT5720 as well as in cells expressing phosphotransferase-deficient TRPM7 constructs. | Cyclic AMP | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 10 | Taken together, our results demonstrate that TRPM7 activity is up- and down-regulated through its endogenous kinase in a cAMP- and PKA-dependent manner. | Cyclic AMP | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |