Pub. Date : 2004 Mar
PMID : 15016328
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Proteasome inhibitor PS-341 down-regulates prostate-specific antigen (PSA) and induces growth arrest and apoptosis of androgen-dependent human prostate cancer LNCaP cells. | Bortezomib | kallikrein related peptidase 3 | Homo sapiens |
| 2 | Proteasome inhibitor PS-341 induces growth arrest and apoptosis of multiple myeloma (MM) cells via inactivation of nuclear factor kappaB (NF-kappaB) in vitro. | Bortezomib | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | In this study, we found that PS-341 induced growth arrest and apoptosis of androgen-dependent human prostate cancer LNCaP cells in conjunction with markedly up-regulated levels of p21(waf1) and p53. | Bortezomib | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 4 | In this study, we found that PS-341 induced growth arrest and apoptosis of androgen-dependent human prostate cancer LNCaP cells in conjunction with markedly up-regulated levels of p21(waf1) and p53. | Bortezomib | tumor protein p53 | Homo sapiens |
| 5 | PS-341 down-regulated basal levels of the androgen receptor (AR) in the nucleus; however, it did not affect DHT-induced nuclear translocation of AR in these cells. | Bortezomib | androgen receptor | Homo sapiens |
| 6 | PS-341 down-regulated basal levels of the androgen receptor (AR) in the nucleus; however, it did not affect DHT-induced nuclear translocation of AR in these cells. | Bortezomib | androgen receptor | Homo sapiens |
| 7 | Reporter assays using a series of promoters of the PSA gene showed that down-regulation of PSA by PS-341 was caused by inhibition of the transcriptional activity of the androgen receptor response element (ARE) in these cells. | Bortezomib | kallikrein related peptidase 3 | Homo sapiens |
| 8 | Reporter assays using a series of promoters of the PSA gene showed that down-regulation of PSA by PS-341 was caused by inhibition of the transcriptional activity of the androgen receptor response element (ARE) in these cells. | Bortezomib | kallikrein related peptidase 3 | Homo sapiens |
| 9 | Reporter assays using a series of promoters of the PSA gene showed that down-regulation of PSA by PS-341 was caused by inhibition of the transcriptional activity of the androgen receptor response element (ARE) in these cells. | Bortezomib | androgen receptor | Homo sapiens |
| 10 | Taken together, the results indicate that PS-341 induced growth arrest and apoptosis of LNCaP cells by blockade of the AR signaling pathway. | Bortezomib | androgen receptor | Homo sapiens |