Title : Mice lacking neuronal nicotinic acetylcholine receptor beta4-subunit and mice lacking both alpha5- and beta4-subunits are highly resistant to nicotine-induced seizures.

Pub. Date : 2004 Apr 13

PMID : 14996991






5 Functional Relationships(s)
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1 Mice lacking neuronal nicotinic acetylcholine receptor beta4-subunit and mice lacking both alpha5- and beta4-subunits are highly resistant to nicotine-induced seizures. Nicotine basic helix-loop-helix family, member e23 Mus musculus
2 The beta4 null mice were remarkably resistant to nicotine-induced seizures compared with wild-type and alpha5 null mice. Nicotine basic helix-loop-helix family, member e23 Mus musculus
3 We also generated mice with double deficiency of both alpha5- and beta4-nAChR subunits and demonstrated that they were more resistant to nicotine"s convulsant effect than either the alpha5 or the beta4 single mutant mice. Nicotine basic helix-loop-helix family, member e23 Mus musculus
4 Our results thus show that beta4-containing nAChRs have a crucial role in the pathogenesis of nicotine-induced seizures. Nicotine basic helix-loop-helix family, member e23 Mus musculus
5 Furthermore, by comparing multiple mutant mice with single and double subunit deficiency, we suggest that nicotinic receptors containing either alpha5- or beta4-subunits are involved in nicotine-induced seizures and that receptors containing both subunits are likely to contribute to this phenomena as well. Nicotine basic helix-loop-helix family, member e23 Mus musculus