Title : Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia.

Pub. Date : 2004 Mar 2

PMID : 14976260






3 Functional Relationships(s)
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1 However, TRPM6 specifically interacted with its closest homolog, the Mg(2+)-permeable cation channel TRPM7, resulting in the assembly of functional TRPM6/TRPM7 complexes at the cell surface. magnesium ion transient receptor potential cation channel subfamily M member 7 Homo sapiens
2 However, TRPM6 specifically interacted with its closest homolog, the Mg(2+)-permeable cation channel TRPM7, resulting in the assembly of functional TRPM6/TRPM7 complexes at the cell surface. magnesium ion transient receptor potential cation channel subfamily M member 7 Homo sapiens
3 Together, our data suggest an important contribution of TRPM6/TRPM7 heterooligomerization for the biological role of TRPM6 in epithelial magnesium absorption. Magnesium transient receptor potential cation channel subfamily M member 7 Homo sapiens