Title : P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study.

Pub. Date : 2003 Dec 16

PMID : 14662702






2 Functional Relationships(s)
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1 BACKGROUND: We recently described a gain-of-function haplotype, called H2, of the adenosine diphosphate (ADP) receptor P2Y12 gene associated with increased ADP-induced platelet aggregation ex vivo in healthy volunteers. Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens
2 CONCLUSIONS: These data point to a role of the H2 haplotype in atherosclerosis and raise the possibility of relative thienopyridine resistance in carriers of the P2Y12 H2 haplotype. thienopyridine purinergic receptor P2Y12 Homo sapiens