Pub. Date : 2003 Nov 1
PMID : 14614022
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. | GPI 15427 | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 2 | In this study, we tested whether systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase (PARP-1) inhibitor capable of crossing the blood-brain barrier, could enhance the efficacy of TMZ against metastatic melanoma, glioblastoma multiforme, and lymphoma growing in the brain. | GPI 15427 | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 3 | CONCLUSIONS: These data indicate that systemic administration of the poly(ADP-ribose) polymerase-1 inhibitor GPI 15427 significantly enhances TMZ antitumor efficacy against solid or hematological neoplasias even when located at the central nervous system site. | GPI 15427 | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |