Pub. Date : 2003 Oct
PMID : 14607107
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. | 2-(phosphonomethyl)pentanedioic acid | folate hydrolase 1 | Rattus norvegicus |
| 2 | It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. | 2-(phosphonomethyl)pentanedioic acid | folate hydrolase 1 | Rattus norvegicus |
| 3 | It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. | 2-(phosphonomethyl)pentanedioic acid | folate hydrolase 1 | Rattus norvegicus |
| 4 | It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. | 2-(phosphonomethyl)pentanedioic acid | folate hydrolase 1 | Rattus norvegicus |
| 5 | It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. | 2-(phosphonomethyl)pentanedioic acid | folate hydrolase 1 | Rattus norvegicus |
| 6 | It is hydrolysed by glutamate carboxypeptidase II (GCPII); thus, the GCP-II inhibitor 2-[phosphono-methyl]-pentanedioic acid (2-PMPA) protects endogenous NAAG from degradation, allowing its effects to be studied in vivo. | 2-(phosphonomethyl)pentanedioic acid | folate hydrolase 1 | Rattus norvegicus |
| 7 | NAAG is an agonist at the inhibitory metabotropic glutamate receptor mGluR3, and 2-PMPA may inhibit nociceptive transmission in normal animals by elevating synaptic NAAG levels, allowing it to activate mGluR3 and thus reducing transmitter release from afferent nerve terminals. | 2-(phosphonomethyl)pentanedioic acid | glutamate receptor, ionotropic, AMPA3 (alpha 3) | Mus musculus |