Title : Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells.

Pub. Date : 2003 Nov 25

PMID : 14605212






1 Functional Relationships(s)
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1 In contrast to FKBP12-/- cells, splenic FKBP12.6-/- T cells exhibited a decreased proliferative response to IL-2 in the presence of rapamycin without affecting p70S6K or ERK activation. Sirolimus FKBP prolyl isomerase 1B Homo sapiens