Pub. Date : 2004 Jan 30
PMID : 14594813
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The TRPM7/ChaK1 channel has been characterized using electrophysiological techniques, and recent evidence suggests that it may play a key role in the regulation of magnesium homeostasis. | Magnesium | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 2 | The TRPM7/ChaK1 channel has been characterized using electrophysiological techniques, and recent evidence suggests that it may play a key role in the regulation of magnesium homeostasis. | Magnesium | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 3 | ChaK1-cat is able to undergo autophosphorylation and to phosphorylate myelin basic protein and histone H3 on serine and threonine residues. | Serine | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 4 | ChaK1-cat is able to undergo autophosphorylation and to phosphorylate myelin basic protein and histone H3 on serine and threonine residues. | Threonine | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 5 | ChaK1-cat is insensitive to staurosporine (up to 0.1 mM) but can be inhibited by rottlerin. | rottlerin | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 6 | Zn(2+) and Co(2+) inhibited ChaK1-cat kinase activity. | Zinc | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 7 | Zn(2+) and Co(2+) inhibited ChaK1-cat kinase activity. | Cobalt(2+) | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 8 | Considering intracellular ion concentrations, our results suggest that, among divalent metal ions, only Mg(2+) can directly modulate TRPM7/ChaK1 kinase activity in vivo. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 9 | Considering intracellular ion concentrations, our results suggest that, among divalent metal ions, only Mg(2+) can directly modulate TRPM7/ChaK1 kinase activity in vivo. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |