Title : Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway.

Pub. Date : 2004 Feb 1

PMID : 14583090






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1 Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway. Bile Acids and Salts mucin 4, cell surface associated Homo sapiens
2 Abnormal gastro-oesophageal reflux and bile acids have been linked to the presence of Barrett"s oesophageal premalignant lesion associated with an increase in mucin-producing goblet cells and MUC4 mucin gene overexpression. Bile Acids and Salts mucin 4, cell surface associated Homo sapiens
3 However, the molecular mechanisms underlying the regulation of MUC4 by bile acids are unknown. Bile Acids and Salts mucin 4, cell surface associated Homo sapiens
4 Since total bile is a complex mixture, we undertook to identify which bile acids are responsible for MUC4 up-regulation by using a wide panel of bile acids and their conjugates. Bile Acids and Salts mucin 4, cell surface associated Homo sapiens
5 Since total bile is a complex mixture, we undertook to identify which bile acids are responsible for MUC4 up-regulation by using a wide panel of bile acids and their conjugates. Bile Acids and Salts mucin 4, cell surface associated Homo sapiens
6 We show that among the bile acids tested, taurocholic, taurodeoxycholic, taurochenodeoxycholic and glycocholic acids and sodium glycocholate are strong activators of MUC4 expression and that this regulation occurs at the transcriptional level. Bile Acids and Salts mucin 4, cell surface associated Homo sapiens
7 We show that among the bile acids tested, taurocholic, taurodeoxycholic, taurochenodeoxycholic and glycocholic acids and sodium glycocholate are strong activators of MUC4 expression and that this regulation occurs at the transcriptional level. taurochenodeoxycholic mucin 4, cell surface associated Homo sapiens
8 We show that among the bile acids tested, taurocholic, taurodeoxycholic, taurochenodeoxycholic and glycocholic acids and sodium glycocholate are strong activators of MUC4 expression and that this regulation occurs at the transcriptional level. Glycocholic Acid mucin 4, cell surface associated Homo sapiens
9 We show that among the bile acids tested, taurocholic, taurodeoxycholic, taurochenodeoxycholic and glycocholic acids and sodium glycocholate are strong activators of MUC4 expression and that this regulation occurs at the transcriptional level. Glycocholic Acid mucin 4, cell surface associated Homo sapiens
10 By using specific pharmacological inhibitors of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase A and protein kinase C, we demonstrate that bile acid-mediated up-regulation of MUC4 is promoter-specific and mainly involves activation of phosphatidylinositol 3-kinase. Bile Acids and Salts mucin 4, cell surface associated Homo sapiens
11 This new mechanism of regulation of MUC4 mucin gene points out an important role for bile acids as key molecules in targeting MUC4 overexpression in early stages of oesophageal carcinogenesis. Bile Acids and Salts mucin 4, cell surface associated Homo sapiens
12 This new mechanism of regulation of MUC4 mucin gene points out an important role for bile acids as key molecules in targeting MUC4 overexpression in early stages of oesophageal carcinogenesis. Bile Acids and Salts mucin 4, cell surface associated Homo sapiens