Pub. Date : 2003 Nov
PMID : 14579029
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. | Serine | mechanistic target of rapamycin kinase | Mus musculus |
| 2 | Insulin-induced phosphorylation of Serine(307) was dependent on the activation of a PI 3-kinase/mTOR pathway. | Serine | mechanistic target of rapamycin kinase | Mus musculus |
| 3 | The phosphorylation of Serine(612/632) required the activation of the MAP kinase pathway following short-term insulin stimulation and activation of the PI 3-kinase/mTOR pathway following prolonged insulin stimulation. | Serine | mechanistic target of rapamycin kinase | Mus musculus |
| 4 | Phosphorylation of Serine(307) and Serine(632) occurred in vivo in skeletal muscle and white adipose tissue of mice injected with insulin and was dependent on the activation of mTOR. | Serine | mechanistic target of rapamycin kinase | Mus musculus |
| 5 | Phosphorylation of Serine(307) and Serine(632) occurred in vivo in skeletal muscle and white adipose tissue of mice injected with insulin and was dependent on the activation of mTOR. | Serine | mechanistic target of rapamycin kinase | Mus musculus |