Title : Purification and functional reconstitution of the human P2Y12 receptor.

Pub. Date : 2003 Nov

PMID : 14573771






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 GTP hydrolysis in proteoliposomes formed with purified P2Y12-R and Galphai2beta1gamma2 was stimulated by addition of either 2-methylthio-ADP (2MeSADP) or RGS4 and was markedly enhanced by their combined presence. Guanosine Triphosphate purinergic receptor P2Y12 Homo sapiens
2 GTP hydrolysis in proteoliposomes formed with purified P2Y12-R and Galphai2beta1gamma2 was stimulated by addition of either 2-methylthio-ADP (2MeSADP) or RGS4 and was markedly enhanced by their combined presence. methylthio-ADP purinergic receptor P2Y12 Homo sapiens
3 ATP had no effect alone but inhibited the action of 2MeSADP; therefore, ATP is a relatively low-affinity antagonist of the P2Y12-R. Adenosine Triphosphate purinergic receptor P2Y12 Homo sapiens
4 ATP had no effect alone but inhibited the action of 2MeSADP; therefore, ATP is a relatively low-affinity antagonist of the P2Y12-R. Adenosine Triphosphate purinergic receptor P2Y12 Homo sapiens