Pub. Date : 1992 Jun
PMID : 1409354
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Structural modification study of anthracyclinones: synthesis and biological activity of several derivatives of eta-pyrromycinone. | anthracyclinones | endothelin receptor type A | Homo sapiens |
| 2 | On the basis of the N-O-O triangular pharmacophore hypothesis postulated earlier in our laboratory, selected side chains with or without the nitrogen atom at the strategic position were incorporated to eta-pyrromycinone, one of the anthracyclinones derived from the antibiotic cinerubins. | n-o-o | endothelin receptor type A | Homo sapiens |
| 3 | On the basis of the N-O-O triangular pharmacophore hypothesis postulated earlier in our laboratory, selected side chains with or without the nitrogen atom at the strategic position were incorporated to eta-pyrromycinone, one of the anthracyclinones derived from the antibiotic cinerubins. | anthracyclinones | endothelin receptor type A | Homo sapiens |
| 4 | On the basis of the N-O-O triangular pharmacophore hypothesis postulated earlier in our laboratory, selected side chains with or without the nitrogen atom at the strategic position were incorporated to eta-pyrromycinone, one of the anthracyclinones derived from the antibiotic cinerubins. | cinerubins | endothelin receptor type A | Homo sapiens |
| 5 | Results indicated that a compound designed in this manner, 1,4-bis[2-(2,2-dimethyloxazolidin-3-yl)ethylamino]-1,4-didehydr oxy-eta- pyrromycinone (9c) possessed both in vitro and in vivo antineoplastic activity comparable to that of mitoxantrone. | 9c | endothelin receptor type A | Homo sapiens |
| 6 | Results indicated that a compound designed in this manner, 1,4-bis[2-(2,2-dimethyloxazolidin-3-yl)ethylamino]-1,4-didehydr oxy-eta- pyrromycinone (9c) possessed both in vitro and in vivo antineoplastic activity comparable to that of mitoxantrone. | Mitoxantrone | endothelin receptor type A | Homo sapiens |