Protein Name endothelin receptor type A
Organism Homo sapiens
Gene ID 1909
Gene Symbol

EDNRA

UniProt P25101 (EDNRA_HUMAN)
Relationships Total Number of functionally related compound(s) : 1710
Total Number of Articles : 1749
Description

endothelin receptor type A

Gene Summary

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

synonyms
  • endothelin-1 receptor
  • G protein-coupled receptor
  • endothelin receptor subtype A
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Properties